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Expression of protease-activated receptors on platelets in healthy individuals

Rui ZHU, Lin SHEN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 236-239 doi: 10.1007/s11684-009-0040-7

Abstract: This study aimed to investigate the expression of protease-activated receptors (PARs) on platelets in

Keywords： protease-activated receptors     platelet    

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High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 69-82 doi: 10.1007/s11684-018-0677-1

Abstract:

Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapy

Keywords： cytokine-activated T cells     high-affinity T cell receptor     cancer immunotherapy     TCR-CAT    

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Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 385-393 doi: 10.1007/s11684-010-0600-x

Abstract: protective ability of host defense system is largely dependent on germ-line encoded pattern-recognition receptorsThe most studied PRRs are Toll-like receptors (TLRs).

Keywords： Toll-like receptors     innate immunity     infectious disease     inflammation    

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Group III metabotropic glutamate receptors and drug addiction

Limin Mao, Minglei Guo, Daozhong Jin, Bing Xue, John Q. Wang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 445-451 doi: 10.1007/s11684-013-0291-1

Abstract: Accumulating data have demonstrated roles of ionotropic glutamate receptors and group I and II metabotropicglutamate receptors (mGluRs) in this event.These presynaptic receptors regulate basal and/or phasic release of respective transmitters to maintain

Keywords： group III metabotropic glutamate receptors     cocaine     amphetamine     alcohol     opiate    

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Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia

Juanjuan Xin,Yangshuai Su,Zhaokun Yang,Wei He,Hong Shi,Xiaoyu Wang,Ling Hu,Xiaochun Yu,Xianghong Jing,Bing Zhu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 465-472 doi: 10.1007/s11684-016-0482-7

Abstract: However, contributions of functional receptors expressed on afferent fibers to the EA analgesia remainthe roles of acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) receptors

Keywords： electroacupuncture     analgesia     ASIC3     TRPV1     C-fiber reflex    

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Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in Review

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Engineering 2022, Volume 10, Issue 3,   Pages 30-43 doi: 10.1016/j.eng.2021.10.018

Abstract:

Chimeric antigen receptors (CARs) are a breakthrough in genetic engineering that have revolutionizedCells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specific

Keywords： Chimeric antigen receptors     T cell     Treg     Alloimmunity     Bioengineering     Transplant     Autoimmunity    

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Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 166-174 doi: 10.1007/s11684-014-0334-2

Abstract:

Chronic hepatitis C virus (HCV) infection afflicts a reported 170 million people worldwide and is often complicated by cirrhosis and hepatocellular carcinoma. Morbidity and mortality are decreased with the successful treatment of chronic HCV infection. Increased understanding of the HCV has allowed further development of new direct-acting antiviral (DAA) agents against the HCV and has also allowed the development of IFN-free oral treatment regimens. In late 2013 the first nucleotide polymerase inhibitor regimen with RBV alone for genotypes 2/3 and in combination with a 12-week regimen of PEG-IFN+RBV for genotypes 1, 4 was approved for use in the US. A number of promising new DAA regimens which are IFN-free are in phase 3 development and the first will likely be approved for use in the US in 2014. The currently approved regimens are discussed in detail and currently available data on future regimens are reviewed herein.

Keywords： direct-acting antiviral (DAA)     nucleotide polymerase inhibitors     protease inhibitors    

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Adsorption of benzene and toluene from waste gas using activated carbon activated by ZnCl

Leila KARIMNEZHAD,Mohammad HAGHIGHI,Esmaeil FATEHIFAR

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 6,   Pages 835-844 doi: 10.1007/s11783-014-0695-4

Abstract: A series of activated carbons with high surface area were prepared from walnut shell using chemical activationThe influence of impregnation ratio on the characteristics of synthesized activated carbons as well asThe synthesized activated carbons were characterized using XRD, SEM, BET and FTIR techniques.The highest activated carbon production yield was obtained at impregnation ratio of 1.5 wt/wt.The surface area of the activated carbons increased with increasing impregnation ratio and its maximum

Keywords： Chemical activation     activated carbon     textural characterization     adsorption     benzene     toluene    

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Influence of pore structure on biologically activated carbon performance and biofilm microbial characteristics

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1419-1

Abstract:

• Pore structure affects biologically activated carbon performance.

Keywords： Granular activated carbon     Biologically activated carbon filter     Bacterial community structure     Pore    

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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two receptors

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract: activation and P-selectin expression and thromboxane B2 production as well as p38 mitogen-activated

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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Removal of phenol by powdered activated carbon adsorption

Yan MA, Naiyun GAO, Wenhai CHU, Cong LI

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 2,   Pages 158-165 doi: 10.1007/s11783-012-0479-7

Abstract: In this study, the adsorption performance of powdered activated carbon (PAC) on phenol was investigated

Keywords： phenol     powdered activated carbon     adsorption     kinetics     isotherms    

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Kinetics and thermodynamics of the phosphine adsorption on the modified activated carbon

Bingnan REN

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 203-208 doi: 10.1007/s11705-010-0571-0

Abstract: The kinetics and the thermodynamics of phosphine (PH ) adsorption on the modified activated carbon haveThis study investigated the kinetic and thermodynamic properties of PH adsorption on the activated carbon

Keywords： adsorption     PH3     activated carbon     kinetics     thermodynamics    

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Responses of microbial interactions to elevated salinity in activated sludge microbial community

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 5, doi: 10.1007/s11783-023-1660-x

Abstract:

● Salinity led to the elevation of NAR over 99.72%.

Keywords： Elevated salinity     Activated sludge system     Pollution removal     Microbial interactions     Competitive relationship    

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A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 275-289 doi: 10.1007/s11684-022-0945-y

Abstract: The abnormal activation of HER family kinase activity is closely related to the development of human malignancies. In this study, we used HER kinases as targets for the treatment of nasopharyngeal carcinoma (NPC) and explored the anti-tumor effects of the novel pan-HER inhibitor HM781-36B, alone or in combination with cisplatin. We found that HER family proteins were positively expressed in tumor tissues of some NPC patients, and the high levels of those proteins were significantly related to poor prognosis. HM781-36B inhibited NPC in vitro and in vivo. HM781-36B exerted synergistic effects with cisplatin on inhibiting proliferation and promoting apoptosis of NPC cells. In NPC xenograft models in nude mice, HM781-36B and cisplatin synergistically inhibited tumor growth. Downregulating the activity of HER family proteins and their downstream signaling pathways and regulating tumor microenvironment may explain the synergistic anti-tumor effects of HM781-36B and cisplatin. In conclusion, our study provides evidence for HER family proteins as prognostic biomarkers and potential therapeutic targets for NPC. The pan-HER inhibitor HM781-36B alone or in combination with cisplatin represents promising therapeutic effects for the treatment of NPC patients, which provides a new idea for the comprehensive treatment of NPC.

Keywords： epidermal growth factor receptor     ErbB receptors     HM781-36B     nasopharyngeal carcinoma     molecular targeted    

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A hybrid membrane process for simultaneous thickening and digestion of waste activated sludge

Zhiwei WANG, Qiaoying WANG, Zhichao WU, Xinhua WANG,

Frontiers of Environmental Science & Engineering 2010, Volume 4, Issue 3,   Pages 272-279 doi: 10.1007/s11783-010-0234-x

Abstract: A hybrid membrane process for simultaneous sludge thickening and digestion (MSTD) was studied. During one cycle (15 d) of operation under a hydraulic retention time of 1 d, the concentration of mixed liquor suspended solids (MLSS) continuously increased from about 4 g·L to 34 g·L, and the mixed liquor volatile suspended solids (MLVSS) increased from about 3 g·L to over 22 g·L. About 42% of the MLVSS and 39% of the MLSS reduction were achieved. The thickening and digestion effects in the MSTD were further analyzed based on a mass balance analysis. Test results showed that biopolymers and cations of biomass were gradually released to the bulk solution during the process. It was also found that the capillary suction time, colloidal chemical oxygen demand, soluble microbial products, viscosity, and MLSS had significant positive correlations with the membrane fouling rate, whereas extracellular polymeric substances, polysaccharides, and proteins extracted from biomass had negative impacts on membrane fouling.

Keywords： membrane filtration     sludge digestion     sludge thickening     waste activated sludge    

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Title Author Date Type Operation

Expression of protease-activated receptors on platelets in healthy individuals

Rui ZHU, Lin SHEN

Journal Article

High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Journal Article

Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Journal Article

Group III metabotropic glutamate receptors and drug addiction

Limin Mao, Minglei Guo, Daozhong Jin, Bing Xue, John Q. Wang

Journal Article

Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia

Juanjuan Xin,Yangshuai Su,Zhaokun Yang,Wei He,Hong Shi,Xiaoyu Wang,Ling Hu,Xiaochun Yu,Xianghong Jing,Bing Zhu

Journal Article

Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in

Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

Journal Article

Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Journal Article

Adsorption of benzene and toluene from waste gas using activated carbon activated by ZnCl

Leila KARIMNEZHAD,Mohammad HAGHIGHI,Esmaeil FATEHIFAR

Journal Article

Influence of pore structure on biologically activated carbon performance and biofilm microbial characteristics

Journal Article

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two receptors

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

Removal of phenol by powdered activated carbon adsorption

Yan MA, Naiyun GAO, Wenhai CHU, Cong LI

Journal Article

Kinetics and thermodynamics of the phosphine adsorption on the modified activated carbon

Bingnan REN

Journal Article

Responses of microbial interactions to elevated salinity in activated sludge microbial community

Journal Article

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma

Journal Article

A hybrid membrane process for simultaneous thickening and digestion of waste activated sludge

Zhiwei WANG, Qiaoying WANG, Zhichao WU, Xinhua WANG,

Journal Article